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Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 187-219 doi: 10.1007/s11684-015-0386-y

Abstract: Since many features also occur in other chronic liver diseases, these scoring systems aid evaluation

Keywords： autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy    

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Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 91-95 doi: 10.1007/s11684-009-0011-z

Abstract: To study the efficacy of Fuganling granula (FGL, 复肝灵颗粒) in treating mouse immunological hepatic injuryadopted, among which, 50 mice were given intraperitoneal injection with BCG and LPS to establish an immunologicalThis experiment established the immunological liver injury model successfully and found that FGL hasa remarkably protective effect on this kind of immunological hepatic injury.

Keywords： Fuganling granula     immunological liver injury     bacille calmette guerin     lipopolysaccharide     mice    

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Emerging immunological strategies: recent advances and future directions

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 805-828 doi: 10.1007/s11684-021-0886-x

Abstract: Immunotherapy plays a compelling role in cancer treatment and has already made remarkable progress. However, many patients receiving immune checkpoint inhibitors fail to achieve clinical benefits, and the response rates vary among tumor types. New approaches that promote anti-tumor immunity have recently been developed, such as small molecules, bispecific antibodies, chimeric antigen receptor T cell products, and cancer vaccines. Small molecule drugs include agonists and inhibitors that can reach the intracellular or extracellular targets of immune cells participating in innate or adaptive immune pathways. Bispecific antibodies, which bind two different antigens or one antigen with two different epitopes, are of great interest. Chimeric antigen receptor T cell products and cancer vaccines have also been investigated. This review explores the recent progress and challenges of different forms of immunotherapy agents and provides an insight into future immunotherapeutic strategies.

Keywords： cancer immunotherapy     bispecific antibodies     small molecules     chimeric antigen receptor T therapy     cancer vaccines    

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: Another major advance is the observation of immunological responses associated with nano-enabled hyperthermiaThis perspective first discusses the temperature-gradient and the spatially-structured immunologicalthe discussion about underlying mechanism such as immunogenic cell death, which initiates a profound immunologicalactivation as a viable therapeutic principle, we further discussed the tumor type-specific complexity in the immunological

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Laparoscopic treatment of liver diseases in children

Jia Wei, Jiexiong Feng

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 388-394 doi: 10.1007/s11684-011-0165-3

Abstract: Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases overapplication of various laparoscopic instruments and the methods used for the laparoscopic treatment of liver diseases

Keywords： laparoscopic surgery     liver mass     pediatric    

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Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 16-20 doi: 10.1007/s11684-010-0007-8

Abstract: Cardiovascular diseases (CVD) cause one third of all deaths in China, and the number is anticipated to

Keywords： cardiovascular diseases     prevalence     China     risk factors     prevention    

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Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 389-394 doi: 10.1007/s11684-013-0281-3

Abstract: Specifically, we suggest that an undiagnosed diseases program in China will differ from the recentlyestablished Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally

Keywords： genetics     cultural differences     undiagnosed diseases program    

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Diagnosis and therapy of lacrimal system diseases by micro lacrimal endoscope

Nan XIANG, Weikun HU, Jing YUAN, Guigang LI, Haixia LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 113-117 doi: 10.1007/s11684-009-0001-1

Abstract: membranes, the characteristics of pathological changes and the predilection sites of lacrimal system diseasesThe lacrimal endoscope is a new method in the diagnosis of lacrimal system diseases.therapy under orthophoria, it will bring a great change to the diagnosis and therapy of lacrimal system diseases

Keywords： lacrimal apparatus diseases     endoscopes    

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Responses to emerging and re-emerging infectious diseases: One world, One health

Jianqing Xu, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 1-2 doi: 10.1007/s11684-018-0619-y

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A Study on the Prevention and Control of Major Chronic Non-communicable Diseases Abroad

Zhang Zhuqin and Liu Depei

Strategic Study of CAE 2017, Volume 19, Issue 2,   Pages 112-116 doi: 10.15302/J-SSCAE-2017.02.019

Abstract:

Major chronic non-communicable diseases, including cardiovascular andcerebrovascular diseases, cancer, respiratory diseases, and diabetes, are prevalent in China and aroundIn order to effectively prevent and control chronic diseases, enhance national health, and promote economicThis project conducted a series of studies on the prevention and control of chronic diseases at homeBased on the project report, this paper describes the prevention and control of various chronic diseases

Keywords： chronic non-communicable diseases     cardiovascular and cerebrovascular diseases     cancer     respiratory diseases    

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of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological

Yuan Gao, Zhilei Wang, Jinfa Tang, Xiaoyi Liu, Wei Shi, Nan Qin, Xiaoyan Wang, Yu Pang, Ruisheng Li, Yaming Zhang, Jiabo Wang, Ming Niu, Zhaofang Bai, Xiaohe Xiao

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 68-80 doi: 10.1007/s11684-019-0690-z

Abstract: traditional Chinese medicine incompatibility, considering that it induces idiosyncratic hepatotoxicity under immunological

Keywords： Epimedii Folium     Psoraleae Fructus     idiosyncratic hepatotoxicity     traditional Chinese medicine incompatibility    

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Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: crucial roles of some special miRNAs in heart development and pathophysiology of various cardiovascular diseasesThis has raised the possibility of using circulating miRNAs as biomarkers for diseases.In this review, we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseases

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

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The critical importance of epigenetics in autoimmune-related skin diseases

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 43-57 doi: 10.1007/s11684-022-0980-8

Abstract: Autoimmune-related skin diseases are a group of disorders with diverse etiology and pathophysiology involvedmechanisms in autoimmune-related skin disorders, including systemic lupus erythematosus, bullous skin diseases

Keywords： epigenetics     autoimmune-related skin diseases     DNA methylation     histone modifications     noncoding RNAs    

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Trends of foodborne diseases in China: lessons from laboratory-based surveillance since 2011

Jikai Liu, Li Bai, Weiwei Li, Haihong Han, Ping Fu, Xiaochen Ma, Zhenwang Bi, Xiaorong Yang, Xiuli Zhang, Shiqi Zhen, Xiaoling Deng, Xiumei Liu, Yunchang Guo

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 48-57 doi: 10.1007/s11684-017-0608-6

Abstract: In this review, we summarize the recent monitoring approach to foodborne diseases in China and compare

Keywords： foodborne diseases     surveillance     TraNet     China    

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Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Infertility is experienced by 8%–12% of adults in their reproductive period globally and has become a prevalent concern. Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation. Remarkable progress has been made in understanding the biology and purpose of stem cells. The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertility induced by premature ovarian insufficiency and azoospermia. Accordingly, this study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem cells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs. These methods have been used to manage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility.

Keywords： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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Title Author Date Type Operation

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Journal Article

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Journal Article

Emerging immunological strategies: recent advances and future directions

Journal Article

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Laparoscopic treatment of liver diseases in children

Jia Wei, Jiexiong Feng

Journal Article

Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Journal Article

Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Journal Article

Diagnosis and therapy of lacrimal system diseases by micro lacrimal endoscope

Nan XIANG, Weikun HU, Jing YUAN, Guigang LI, Haixia LIU

Journal Article

Responses to emerging and re-emerging infectious diseases: One world, One health

Jianqing Xu, Jianguo Xu

Journal Article

A Study on the Prevention and Control of Major Chronic Non-communicable Diseases Abroad

Zhang Zhuqin and Liu Depei

Journal Article

of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological

Yuan Gao, Zhilei Wang, Jinfa Tang, Xiaoyi Liu, Wei Shi, Nan Qin, Xiaoyan Wang, Yu Pang, Ruisheng Li, Yaming Zhang, Jiabo Wang, Ming Niu, Zhaofang Bai, Xiaohe Xiao

Journal Article

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

The critical importance of epigenetics in autoimmune-related skin diseases

Journal Article

Trends of foodborne diseases in China: lessons from laboratory-based surveillance since 2011

Jikai Liu, Li Bai, Weiwei Li, Haihong Han, Ping Fu, Xiaochen Ma, Zhenwang Bi, Xiaorong Yang, Xiuli Zhang, Shiqi Zhen, Xiaoling Deng, Xiumei Liu, Yunchang Guo

Journal Article

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism

Journal Article